KRISHNAN SUMA,OBERLENDER ROB,LAUDERBACK CHRISTOPHER,MICKLE TRAVIS,BISHOP BARNEY,MONCRIEF JAMES SCOTT
申请号：
IN2683/KOLNP/2005
公开号：
IN250464B
申请日:
2005.12.23
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The invention describes compounds compositions and methods or using the some comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
