Indiana University Research and Technology Corporation
发明人:
申请号：
EP08713455.7
公开号：
EP2124974B1
申请日:
2008.01.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
