RESEARCH TRIANGLE INSTITUTE;DIGNITY HEALTH DOING BUSINESS AS ST. JOSEPH'S HOSPITAL MEDICAL CENTER AND BARROW NEUROLOGICAL INSTITUTE;VIRGINIA COMMONWEALTH UNIVERSITY
发明人:
申请号：
EP11723156.3
公开号：
EP2571859B1
申请日:
2011.05.20
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
