ANDRIES, KOENRAAD JOZEF LODEWIJK MARCEL,安卓斯,安卓斯,VAN GESTEL, JOZEF FRANS ELISABETHA,范斯特,范斯特
申请号：
TW094117334
公开号：
TWI363625B
申请日:
2005.05.27
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
It is that the quinoline quinoline for having Off to replace using The spreads out raw object System Prepare Drug Elixirs to control the purposes of point branch Rod bacteria strain infection of Treatment tool Drug objects resistances that this Hair is bright, quinoline As root According following formulas (Ia) that wherein The The replace or the acid being subjected on the compound of formula (Ib) its Medical Drug or Alkaline add into Which, its found Body Iso Agencies objects type, its mutual Change Iso Agencies objects type and its N- oxide types. This Hair is bright also to have a Seed Medical Drug Group at object, and packet includes the Load Elixirs being subjected on Medical Drug and effective mono- or more Seed of above compound With for controlling Treatment amounts, and other resist point branch Rod bacterium Elixirs to make As active constituents.本發明乃有關使用經取代的喹啉衍生物製備藥劑以治療具藥物抗性的分支桿菌菌株感染之用途,其中該經取代的喹啉衍生物為根據下式(Ia)或式(Ib)之化合物其醫藥上可接受之酸或鹼加成鹽、其立體異構物型、其互變異構物型及其N-氧化物型。本發明亦有一種醫藥組成物,其包括醫藥上可接受之載劑及有效治療量之上述化合物與一或多種其他抗分支桿菌劑作為活性成分。
