抑制LPA之基因表現之組合物及方法农业专利-农业学术服务平台

发明人:: MELQUIST, STACEY,梅尔柯斯特　史黛西,梅爾柯斯特　史黛西,KANNER, STEVEN,坎纳　史蒂芬,坎納　史蒂芬,B ROZEMA, DAVID B.,罗兹马　大卫,羅茲馬　大衛,L LEWIS, DAVID L.,路易士　大卫,路易士　大衛,J ALMEIDA, LAUREN J.,阿梅塔　罗伦,阿梅塔　羅倫,H WAKEFIELD, DARREN H.,维克菲尔德　戴伦,維克,梅尔柯斯特史黛西,梅爾柯斯特史黛西,坎纳史蒂芬,坎納史蒂芬,罗兹马大卫,羅茲馬大衛,路易士大卫,路易士大衛,阿梅塔罗伦,阿梅塔羅倫,维克菲尔德戴伦

摘要：: RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.本發明描述用於抑制LPA(apo(a))基因之表現的RNA干擾(RNAi)劑及RNAi劑結合物。本發明亦描述包含一或多種LPA RNAi劑與視情況存在之一或多種額外治療劑的醫藥組合物。將該等描述之LPA RNAi劑遞送至活體內肝細胞提供LPA基因表現之抑制及心血管疾病及心血管相關之疾病之治療。