The present invention relates to reconstituable hydrogel powder of dapsone nanosponges useful in the treatment of acne. The present invention particularly relates to reconstituable hydrogel powder of dapsone nanosponges, which comprises dapsone, porous nanosponges forming pharmaceutically acceptable polymers, raw milk of donkey, pharmaceutically acceptable gelling polymer and preservatives. The reconstituable hydrogel powder of dapsone nanosponges of present invention has potential for treatment of acne.