ITZHAK E. LERNER;ERWIN V. ACHTHOVEN;HANS KEEGSTRA;BARAK MOSHE FLASHNER;TEVA PHARMACEUTICAL INDUSTRIES LTD.;RUUD SMIT
发明人:
ITZHAK E. LERNER,ERWIN V. ACHTHOVEN,HANS KEEGSTRA,RUUD SMIT,BARAK MOSHE FLASHNER
申请号：
IL17838406
公开号：
IL178384A
申请日:
2006.09.28
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention provides enterically coated formulations of 6-mercaptopurine that exhibit a delay in release of the 6-mercaptopurine such that substantial release of 6-mercaptopurine does not occur until after passage through the stomach. Optionally, the formulations also comprise a delay coating in addition to the enteric coating that provides an even further delay such that substantial release of 6-mercaptopurine does not occur until after a certain period of time following passage through the stomach. Such a period of time is preferably at least one hour after passage through the stomach. Following the delay imparted by the enteric coating and optional delay coating, the formulations exhibit better bioavailability and faster dissolution than previous formulations.
