КЛАТРАТНЫЙ КОМПЛЕКС ЦИКЛОДЕКСТРИНА ИЛИ АРАБИНОГАЛАКТАНА ИЛИ ГУММИАРАБИКА С 20-ГИДРОКСИЭКДИЗОНОМ, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО
ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ЛУФАТЕН" (RU)
发明人:
Розиев Рахимджан Ахметджанович (RU),Гончарова Анна Яковлевна (RU),Еримбетов Кенес Тагаевич (RU),Подгородниченко Владимир Константинович (RU)
申请号：
RU2013154195/15
公开号：
RU2013154195A
申请日:
2013.12.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. cyclodextrin clathrate complexes of gum arabic or arabinogalactan or from 20-hydroxyecdysone, at a weight ratio of 20-hydroxyecdysone: cyclodextrin from 1: 2 to 1:25 or at a weight ratio of 20-hydroxyecdysone: arabinogalactan from 1: 1 to 1:20 or in mass ratio of 20-hydroxyecdysone: gum arabic from 1: 1 to 1: 20.2. Clathrate complex according to Claim. 1, according to which it is in crystalline forme.3. Clathrate complex according to claim. 2, according to which it is in the form of nanoparticles with a size less than 100 nm.4. . Clathrate complex according to claim 1, wherein the cyclodextrin is α-, β-, γ - or hydroxypropyl - β-tsiklodekstrin.5. Clathrate complex according to claim 1 or 2, wherein the weight ratio of 20-hydroxyecdysone:. Cyclodextrin, preferably β-cyclodextrin, corresponding to 1: 2 and 1: 10.6. Clathrate complex according to claim 1 or 2, in which the weight ratio of 20-hydroxyecdysone:. Arabinogalactan corresponds to 1: 5 and 1: 10.7. Clathrate complex according to claim 1 or 2, in which the weight ratio of 20-hydroxyecdysone:. Acacia corresponds to 1: 5 and 1: 10.8. Clathrate complex according to Claim. 1 having antidiabetic activity aktivnostyu.9. Clathrate complex according to Claim. 1 having hypolipidemic deystviem.10. A liquid phase process for producing a clathrate complex of cyclodextrin or arabinogalactan and gum arabic with the 20-hydroxyecdysone by n. 1, characterized in that the previously prepared aqueous solution of the appropriate starting cyclodextrin or arabinogalactan or gum arabic and a solution of 20-hydroxyecdysone in an organic solvent immiscible with water such as acetone were mixed under stirring and heating to a temperature in1. Клатратный комплекс циклодекстрина или арабиногалактана или гуммиарабика с 20-гидроксиэкдизоном, при массовом соотношении 20-гидроксиэкдизон: циклодекстрин от 1:2 до 1:25 или при массовом соотношении 20-гидроксиэкдизон: арабиногалактан от 1:1 до 1:20 или при массовом соотношении 20-гидроксиэкдиз
