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ADDRESSING TRUSTUSUMAB-RESISTANT HER2 + BREAST CANCER BY HER3-TARGETED NANOPARTICLES
专利权人:
СИДАРС-СИНАЙ МЕДИКАЛ СЕНТР (US)
发明人:
МЕДИНА-КАУВЕ Лали К. (US),СИМС Джессика (US),ТАГУЭЙМ Майкл (US),ХЭНСОН Крис (US),ЦУЙ Сяоцзян (US)
申请号:
RU2016140214
公开号:
RU2016140214A
申请日:
2015.04.04
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2 therapy; and administering to the patient a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemical agent non-covalently linked to the nucleic acid sequence. Also disclosed are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with the drug delivery molecule. Further disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to anti-HER2 therapy; and administering to the patient a therapeutically effective amount of a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence. Finally disclosed herein are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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