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Bispecific single CHAIN ​​PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES
专利权人:
Amgen Research (Munich) GmbH
发明人:
KUFER, Peter,RAUM, Tobias,KISCHEL, Roman,LUTTERBÜSE, Ralf,HOFFMANN, Patrick,RAU, Doris,MANGOLD, Susanne,KLINGER, Matthias,SCHALLER, Evelyne,HAUSMANN, Susanne,FLUHR, Petra,STEIGER, Carola
申请号:
DK09783664
公开号:
DK2356153T3
申请日:
2009.10.01
申请国别(地区):
DK
年份:
2016
代理人:
摘要:
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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