Margaret Anne Brimble;Paul William Richard Harris;Frank Sieg
发明人:
Paul William Richard Harris,Margaret Anne Brimble,Frank Sieg
申请号：
US12754937
公开号：
US08309684B2
申请日:
2010.04.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Embodiments of this invention include synthetic compounds (NRP analogues) of peptides termed neural regeneration peptides (NRPs). NRP analogues are made by substituting amino acids in the native peptide sequence, modifying amino acids chemically, by replacing amino acids with synthetic moieties, by stabilizing β-turns, acetylation of terminal glycine residues or by cyclization. NRP analogues can be used to treat a variety of conditions involving degeneration of neural cells, and includes treating disorders of the nervous system, including peripheral neuropathy, multiple sclerosis, diabetic peripheral neuropathy, neurotoxin-induced neurodegeneration, and amyotrophic lateral sclerosis.
