JAMES ANDYA,CHUNG C. HSU,JANET YU-FENG YANG,SYLVIA SAU-YAN WU,JEFFREY L. CLELAND,XANTHE M. LAM,DAVID E. OVERCASHIER,STEVEN J. SHIRE
申请号：
PT04022777
公开号：
PT1516628E
申请日:
1996.07.23
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
