Thomas Nixey;Victor J. Cee;Liping H. Pettus;Hui-Ling Wang;Andrew Tasker;Claire L. M. Jackson;Anthony B. Reed;Ryan Wurz;Bradley J. Herberich;Brian Alan Lanman;Bin Wu
发明人:
Hui-Ling Wang,Victor J. Cee,Bradley J. Herberich,Claire L. M. Jackson,Brian Alan Lanman,Thomas Nixey,Liping H. Pettus,Anthony B. Reed,Bin Wu,Ryan Wurz,Andrew Tasker
申请号：
US14006285
公开号：
US09321756B2
申请日:
2012.03.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
