KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
CHO, Kyu Won,조규원,PARK, Mi Ra,박미라,PARK, Young Woo,박영우,JO, Ki Won,조기원,PARK, Chan Woong,박찬웅,YOO, Seok Ho,유석호,JANG, Myeoung Hee,장명희,KIM, Hye Nan,김혜난,YUN, Seon Ha,윤선하
申请号：
KRKR2012/004395
公开号：
WO2012/165925A2
申请日:
2012.06.04
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a human antibody which specifically bonds to c-Met and which consists of: a complementarity-determining region (CDR) and a framework region (FR), both regions being derived from humans. The present invention also relates to a polynucleotide encoding said human antibody, to an expression vector comprising said polynucleotide, to a transformant transformed by said expression vector, to a method for preparing human antibody B7 by culturing said transformant, to a wound-healing composition comprising said human antibody as an active ingredient, to a cell-regenerating composition comprising said human antibody as an active ingredient, and to an antibody-drug conjugate in which a drug is linked to said human antibody. The human antibody specific to c-Met according to the present invention works as a mimic of HGF and therefore may be used as a wound-healing composition. The human antibody of the present invention may be widely utilized in the treatment and prognosis of various diseases which may be healed by the activation of said HGF or c-Met (e.g., neuronal infarction, progressive nephropathy, cirrhosis of the liver, lung fibrosis, kidney, liver, or lung injuries, and ulcerated wounds).La présente invention concerne un anticorps humain qui se lie spécifiquement à c-Met et qui consiste en une région de détermination de complémentarité et en une région charpente, ces deux régions provenant dhumains. Linvention porte en outre sur les éléments suivants : un polynucléotide codant pour ledit anticorps humain un vecteur dexpression comprenant ledit polynucléotide un transformant transformé par ledit vecteur dexpression un procédé de préparation dun anticorps humain B7 par mise en culture dudit transformant une composition pour la guérison de blessure comprenant ledit anticorps humain en tant que principe actif une composition de régénération cellulaire comprenant ledit anticorps humain en tant que principe actif et un conjugué anticorps-mé
