化学的に反応性の非天然アミノ酸を使用するキャリア-ペプチド接合体の製造

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专利权人:

ザ スクリプス リサーチ インスティテュート

发明人:

トラビス・ヤング,ペータ・ジー・シュルツ

申请号：

JP2016053368

公开号：

JP6359046B2

申请日:

2016.03.17

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/