Feng Xiao,Xiao-Chi Jia,Meina Liang,Orit Foord,Scott Klakamp,Kam Fai Tse,Vincent A. Pollack,Luca Rastelli,John Herrmann,Henri Lichenstein,Michael E. Jeffers,William J. LaRochelle,Gulshan Ara,Peter Meze
申请号：
US15053204
公开号：
US20160311919A1
申请日:
2016.02.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
