Crystalline Forms of Benzoquinoline Inhibitors of Vesicular Monoamine Transporter 2

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专利权人:

Apotex Inc.

发明人:

Fabio E.S. Souza,Bahareh Khalili,Allan W. Rey

申请号：

US16410248

公开号：

US20190343815A1

申请日:

2019.05.13

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention provides crystalline forms of Deutetrabenazine. Specific crystalline forms provided by the present invention include Deutetrabenazine Form APO-I, a co-crystal of Deutetrabenazine and quercetin, and Deutetrabenazine Form APO-II, a co-crystal of Deutetrabenazine and luteolin. Also provided are pharmaceutical compositions including the Deutetrabenazine crystalline forms, and the use of these forms in the treatment of tardive dyskinesia and chorea associated with Huntington's disease.

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