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TRITERPENE DERIVATIVES OF LUPEOL TYPE AS ANTIVIRAL PREPARATIONS
专利权人:
KHETERO RISERCH FAUNDEJSHN
发明人:
PARTKhASARADKhI REDDI Bandi (IN),ПАРТХАСАРАДХИ РЕДДИ Банди (IN),MANOKhAR SKhARMA Vedula (IN),МАНОХАР СХАРМА Ведула (IN),RATKhNAKAR REDDI Kura (IN),РАТХНАКАР РЕДДИ Кура (IN),MADKhANMOKhAN REDDI Musku (,PARTKHASARADKHI REDDI BANDI,ПАРТХАСАРАДХИ РЕДДИ Банди,MANOKHAR SKHARMA VEDULA,МАНОХАР СХАРМА Ведула,RATKHNAKAR REDDI KURA,РАТХНАКАР РЕДДИ Кура,MADKHANMOKHAN REDDI MUSKU,МАДХАНМОХАН РЕДДИ Муску,ELLA RE
申请号:
RU2012104993/04
公开号:
RU0002561604C2
申请日:
2010.07.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel triterpene derivatives of formulaand formulaactive with respect to HIV, as well as HIV-mediated diseases, and to an intermediate compound of formulaIn the general formula (I) R stands for H, substituted or non-substituted C1-6 alkyl, benzyl or substituted or non-substituted C4-5 cycloalkyl and preferably R is substituted with Ra; R' stands for H, substituted or non-substituted C1-6 alkyl, substituted or non-substituted C4-5 cycloalkyl, substituted or non-substituted C4-5 cycloalkenyl,substituted piperazinyl, substituted piperidinyl, substituted 8-azabicyclo[3.2.1]octane, 4-ethyl-2,2,6-trimethyl-1.3-dioxane, hexane-2,4-diol or (S)-1-((4aS,8aS)-octahydroisoquinolin-2(1H)-yl)-4-phenylbutan-2-ol and preferably R′ can be substituted with Ra; X is selected from a bond and -C(O)-; X1 is selected from -C(O)-, -C(O)2- or -C(O)NR"-; Z stands for -O-; Z1 stands for a bond; Z' stands for H; n equals 0; m equals 1,″″ stands for a single bond; R1 stands for H; R2 stands for -C(=CH2)(CH3); Ra stands for cyano, phenyl, benzyl, ethyl, 3-isopropyl-5-methyl-1,2,4-triazole, -C(O)2R", -C(O)R", -CH2OR", -C(O)N(R)"2 or substituted or non-substituted C1-6 alkyl, where the substituent is selected from -OH, morpholinyl, benzyl, -COOMe, piperazinyl, optionally substituted with ethyl, piperidinyl, optionally substituted with methyl, -COOH, or benzyl; and each R" is independently selected from H, substituted or non-substituted C1-6 alkyl, methyl 3-methylbutanoate, 3-methylbutanic acid, 4-methylpentanic acid, methyl 4-methylpentanoate, methyl propionate, propanoic acid, 1-morpholinopropan-1-one, 1-(pyrrolidin-1-yl)propan-1-one, 4-ethylpiperazinyl, morpholinyl, piperidinyl, optionally substituted with -COOEt, pyrrolidinyl or benzyl. In formula (2A) XA1 stands for a bond or -C(O)-; XA2 stands for a bond, O or NH; RA1 stands forRb stands for substituted or non-substituted C1-6 alkyl; RA2 stands for substituted or non-substituted a
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