POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2,5-DIHYDRO-4-IMIDAZO[1,2-A]PYRIDINE-3-YL-2,5-DIOXO-1H-PYRROL-3-YL)-9-FLUORO-1,2,3,4-TETRAHYDRO-2-(1-PIPERIDINYL-CARBONYL)-PYRROLO[3,2,1-JK][1,4]BENZODIAZEPINE

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专利权人:

ELI LILLY AND COMPANY

发明人:

ABURUB, AKTHAM,CHEDID, MARCIO,ENGLER, THOMAS, ALBERT,VASUDEVAN, VENKATRAGHAVAN

申请号：

NZ58135508

公开号：

NZ581355A

申请日:

2008.06.20

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is 7-(2,5-dihydro-4-(imidazo[1,2-a]pyridine-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(piperidin-1-ylcarbonyl)-pyrrolo[3,2,1-jk][1,4]-benzodiazepine or a pharmaceutically acceptable salt or solvate thereof in combination with a chemotherapeutic agent selected from CPT-11, 5-fluorouracil, pemetrexed, gemcitabine, etoposide, doxorubicin, and platinum chemotherapeutic agents such as cisplatin or carboplatin for use in the treatment of ovarian cancer, non-small cell lung cancer, colorectal cancer or gastric cancer.

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