JOSE MARIA CID-NUNEZ,ANDRES AVELINO TRABANCO-SUAREZ,GREGOR JAMES MACDONALD,GUILLAUME ALBERT JACQUES DUVEY,ROBERT JOHANNES LUETJENS
申请号：
BRPI0808697
公开号：
BRPI0808697A2
申请日:
2008.03.07
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (mGluR2) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
