ELORANTA, MAIRE,HIRVELA, LEENA,KANGAS, LAURI,KOSKIMIES, PASI,LAMMINTAUSTA, RISTO,UNKILA, MIKKO
申请号：
TW103121873
公开号：
TW201512215A
申请日:
2014.06.25
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R6 are as defined in the claims. The invention further relates to their use as inhibitors of 17 [beta]-HSD1 and in treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17 [beta]-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.本發明有關式（I）化合物以及其醫藥上可接受的鹽類□其中R1至R6是如同申請專利範圍中所定義者。本發明更有關它們作為17β-HSD1抑制劑以及在治療或預防類固醇荷爾蒙依賴型疾病或失調的用途，例如需要該抑制17β-HSD1酵素及/或需要降低內生性雌二醇濃度的類固醇荷爾蒙依賴型疾病或失調。本發明也有關前述化合物的製備以及有關包含一或更多種前述化合物或其醫藥上可接受的鹽類作為活性成分的醫藥組成物。
