A method for confined and controlled treatment of a target area of an internal body lumen using negative pressure applied to the target area, the method permitting treatment to proceed without interrupting the flow of bodily fluid through the body lumen, the method including deploying a resilient stent having a liner to define the target area and passages within the liner connected to a catheter tube so that the negative pressure may be applied through a lumen of the catheter tube from a source connected to the catheter tube without impacting the inflated stent and without impacting the ability of body lumen fluid to flow through the stent, thereby permitting therapy to proceed without disrupting the natural flow of bodily fluids or the delivery of nutrients within the body lumen during therapy.
