Tony R. Reid,Bryan T. Oronsky,Farah Hedjran,Christopher Larson
申请号：
US16482049
公开号：
US20190352669A1
申请日:
2018.01.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides, e.g., a recombinant virus comprising (i) a modified TATA box-based promoter, and/or (ii) a modified CAAT box-based promoter operably linked to a gene, wherein the modified TATA box-based promoter and/or modified CAAT box-based promoter lacks a functional TATA box and/or CAAT box and permit selective expression of the gene in a hyperproliferative cell. The recombinant viruses can be used to treat cell proliferative diseases and disorders, including certain forms of cancer.
