John P. Levy,Rebecca A. Reed,Joseph McNulty,Robert G. Johnson, Jr.
申请号：
US15994999
公开号：
US10350302B2
申请日:
2018.05.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
