The present technology relates generally to an expandable shelter system, and more particularly to a mobile expandable shelter system with a sterilization processing facility. In embodiments, the shelter system comprises, for example, a mobile shelter comprising a decontamination area with a decontamination area air pressure, a sterilization area physically segregated from the decontamination area with a sterilization area air pressure at least one wall configured to isolate the sterilization area from the decontamination area, and an HVAC system configured to keep decontamination area air pressure lower than sterilization area air pressure.
