Centro de Investigacion Cientifica Y de Educacion Superior de Ensenada; Baja California (CICESE)
发明人:
Alexei Fedorovish Licea Navarro,Jose Felix Olivares Quintero,Ana Paola Gutierrez Ordonez
申请号：
US14380863
公开号：
US09284360B2
申请日:
2013.02.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to an isolated or recombinant protein from the shark Heterodontus francisci, which has bovine-erythrocyte-recognition activity and which can bind to sequences of antigens and/or proteins that are characteristic of infectious diseases. Once the aforementioned protein is bound to specific antigens of infectious diseases, it can haemagglutinate upon recognizing the bovine erythrocytes and antibodies characteristic of said diseases, which are present in the active state in biological samples such as whole blood, plasma or serum of bovine origin. The invention also relates to methods for protecting the detection of antibodies characteristic of infectious diseases, using the purified periplasmic extract or fusion protein, optionally purifying the recombinant protein.
