Disclosed is a use of a polypeptide compound having dual agonistic effects on the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The polypeptide compound has the characteristics of a high enzymolysis stability, a high biological activity and zero adverse reaction, etc., can obviously inhibit the fibrosis transformation and proliferation of human pulmonary epithelial cells induced by TGF-[beta]1, and can obviously improve the degree of pulmonary fibrosis in mice induced by bleomycin. Such a dual target agonist polypeptide can be used for preventing or treating pulmonary diseases indicated by fibrotic symptoms.本發明涉及一類具有胰高血糖素樣肽-1受體（Glucagon-like peptide-1 receptor，GLP-1R）和胰高血糖素受體（Glucagon receptor，GCGR）雙激動效應的多肽化合物的用途，其具有高酶解穩定性、高生物活性、無不良反應等特點，能夠明顯抑制TGF-β1誘導的人肺上皮細胞成纖維化轉化增殖，能明顯改善博萊黴素誘導的小鼠肺纖維化程度。該類雙靶點激動劑多肽可用於預防或治療以纖維化症狀為指症的肺病。
