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Carboxamidas fluorometilo substituted pyrrole
专利权人:
GRÜNENTHAL GMBH
发明人:
申请号:
ARP130103069
公开号:
AR092279A1
申请日:
2013.08.29
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Voltage activated calcium channel blockers, pharmaceutical components containing these compounds, and the use of these compounds to treat and / or prevent pain and other diseases and / or disorders. 1. Claim 1: compound (1) of general formula,characterized in that n represents 0, 1 or 2; m represents 0 or 1 with the condition that n ³ m; X is selected from the group consisting of O, S, NH and N-C₁₋₆ alkyl;R1,R2 and R3,a. Select one person from class h, class F, class Cl, class BR, class I and class no832222 respectively;CN; C₁₋₆ alkyl;CF CF H CFH CF Cl CFClC (= O) - H; C (= O) - tar c833131;C (= O) - Oh; C (= O) - o-tar c8332131 = 832626;C (3DO) -N (H) (OH)C (3DO) -NHC(=O)N(H)(alquilo C₁₋₆);C (3DO) -N (alquilo C)C (3DN-OH) -H C 3D (N-OH) -alquilo CC (= n-o-lessor c8321);OH OCF OCF H OCFH OCF Cl OCFClO-c83218c831832626;O-C (3DO) -alquilo CO-C (3DO) -O-alquilo CO - (C = O) - n (H) (rent c832131; 832626);O-C (= O) N (C₁₋₆ alkyl) ₂;O-S (= O) ₂-C₁₋₆-alkyl;O-S (= O) ₂-OH; O-S (= O) ₂-O-C₁₋₆ alkyl;O-S (3DO) -NHO-S (3DO) -N (H) (alquilo C)O-S (3DO) -N (alquilo C)NH.83222;N(H)(alquilo C₁₋₆);N (lease No. c8332121) 833183226;Rent n (H) - C (= O) - c83218c83226;N (H) - C (= O) - o-tar c832138;N (H) -C (3DO) -NHN (H) - C (o) - n (H) (asphalt c832131;N (H) -C (3DO) -N (alquilo C)N (C₁₋₆ alkyl) -C (= O) -C₁₋₆ alkyl;N (c83218c83326) - C (= O) - o-tar c83321c8326);N (alquilo C) -C (3DO) -NHN (alquilo C) -C (3DO) -N (H) (alquilo C)N (c83218c83318c833222) - C (= O) - n (pitch c83218c833222);N (H) -S (3DO) OH N (H) -S (3DO) -alquilo CN(H)-S(=O)₂-O-alquilo C₁₋₆;N (H) -S (3DO) -NHN (H) -S (3DO) -N (H) (alquilo C)N (H) -S (3DO) N (alquilo C)N (alquilo C) -S (3DO) -OH N (alquilo C) -S (3DO) -alquilo CN (alquilo C) -S (3DO) -O-alquilo CN (alquilo C) -S (3DO) -NH N (alquilo C) -S (3DO) -N (H) (alquilo C)N (alquilo C) -S (3DO) -N (alquilo C)SH SCF SCF H SCFH SCF Cl SCFClS-lease c83218c31832626;S (= O) -C₁₋₆ alkyl;S (= O) 832222 - c83218c rent;S (= O) ₂-OH; S (= O) ₂-O-C₁₋₆ alkyl;S (3DO) -NHS
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