The present invention provides a new method of ameliorating and/or treatingenteritis induced by radiation therapy, alone or in combination with othertherapies, for the treatment of, for example, gastrointestinal malignancies,including colorectal, appendiceal, anal, or small bowel cancers; urogenitalmalignancies, including prostate, ladder, testicular, or penile cancers;gynecologic malignancies, including cervical, endometrial, ovarian, vaginal,or vulvar cancers; or osteogenic and other sarcomatous malignancies in whichpelvic structures are involved, comprising the administration of atherapeutically effective amount of balsalazide to a patient in need thereof.