Juan Fueyo,Candelaria Gomez-Manzano,W. K. Alfred Yung,Charles A. Conrad,Frederick F. Lang, Jr.
申请号：
US14703876
公开号：
US10080774B2
申请日:
2015.05.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
