CELL SPECIFIC LABELING OF NEWLY SYNTHESIZED PROTEINS

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专利权人:

Ruth Barrett;Haihong Jin;Michael Cohen

发明人:

Michael Cohen,Ruth Barrett,Haihong Jin

申请号：

US14978700

公开号：

US20160176919A1

申请日:

2015.12.22

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Disclosed herein are compositions comprising blocked puromycin analogs that are converted into active puromycin analogs upon the activity of a penicillin acylase. Also disclosed are methods of using blocked puromycin analogs to label proteins in a selected cell type in vivo in a transgenic multicellular organism that expresses a penicillin acylase within the selected cell type. Also disclosed are transgenic mice expressing a penicillin acylase within a selected cell type.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/