Purpose of this invention is to offer method and the expedient which are improved the tumor inside the epithelium of the outside genital organs, the neck, the vagina, the penis and the anus of HPV inductivity (VIN, CIN, VAIN, PIN and AIN) etc remedying of the tumor inside the virus inductive epithelium of the anus sexual organs at the time of. As for this invention, in step and next it decides whether it has possessed the T cell reactivity at least first the suffering inspection person virus characteristic early for the antigen and the especially high risk type HPV antigen, the suffering inspection person the T cellularity reaction, desirably concerning the CD4+ reaction HPV early for the antigen when as positivity it is decided, remedy method of the suffering inspection person who includes with the step which does the local remedy by the immunity modification chemical compound which induces the local inflammation to the tumor inside the anus epithelium has contracted a disease is offered. In addition as for this invention, the remedy front stirrup by the immunity adjustment chemical compound which can induce the local inflammation reaction after the remedying induction or furthermore method and the expedient which are stimulated includes the cell immunity reaction for the HPV antigen.本発明の目的は、HPV誘導性の外陰部、頸部、膣、陰茎及び肛門の上皮内腫瘍(VIN、CIN、VAIN、PIN及びAIN)などの肛門性器部のウイルス誘導性上皮内腫瘍の治療において改良された方法及び手段を提供することである。本発明は、少なくともまず被検者がウイルス性早期抗原、特にハイリスクタイプHPV抗原に対するT細胞反応性を有しているかを決定するステップと、次に被検者がT細胞性反応、好ましくはHPV早期抗原に対するCD4+反応について陽性と判定される場合、局部炎症を誘発する免疫変更化合物による局部治療を行うステップとを含む、肛門部上皮内腫瘍に罹患している被検者の治療方法を提供する。本発明はまた、局部炎症反応を誘発することができる免疫調節化合物による治療前又は治療後にHPV抗原に対する細胞免疫性反応を誘導又はさらに刺激する方法及び手段も含む。
