Tracy Perry;Nigel H. Greig;Josephine M. Egan;Harold W. Holloway;Maire Doyle
发明人:
Nigel H. Greig,Josephine M. Egan,Maire Doyle,Harold W. Holloway,Tracy Perry
申请号：
US13594313
公开号：
US08853160B2
申请日:
2012.08.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
