AMORO, EDWIN,VANACKERE, KAREL,WHITE, MICHAEL, A. A,．懷特,埃德溫.阿莫羅,卡雷爾.瓦納克,邁克爾.,.懷特
申请号：
HK13100310.8
公开号：
HK1173647B
申请日:
2013.01.09
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.
