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Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine
专利权人:
发明人:
Jean-Michel Lerestif,Jean-Pierre Lecouve,Daniel Dron,Eric Gojon,Maryse Phan
申请号：
US13850514
公开号：
US08778930B2
申请日:
2013.03.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Process for the optical resolution of the compound of formula (I):by chiral chromatography.Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
来源网站：
中国工程科技知识中心
来源网址：
http://www.ckcest.cn/home/
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PROCESS FOR THE SYNTHESIS OF 3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBONITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
PROCESS FOR THE SYNTHESIS OF 3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBONITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
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ПРИМЕНЕНИЕ ИВАБРАДИНА В КАЧЕСТВЕ ДИАГНОСТИЧЕСКОГО СРЕДСТВА В МЕТОДЕ КОРОНАРНОЙ АНГИОГРАФИИ ПУТЕМ МНОГОСЛОЙНОЙ КОМПЬЮТЕРНОЙ ТОМОГРАФИИ
Procedure for the synthesis of 3,4 - dimetoxibiciclo [4.2.0] octa - 1,3,5 - 7 - carbonitrilo triennium 2008-2010, and application to the synthesis of Ivabradine and its acid Addition salts of a farmac u00c9uticamente acceptable
