Citrus-based antimicrobial compositions having broad spectrum antimicrobialactivity againstmicroorganisms such as bacteria, yeast, molds and fungi are described. Thecitrus-based antimicrobial compositionsare suitable for use in food products, personal care products, oral products,or as surface/topical antimicrobials. Theantimicrobial compositions generally comprise citrus extract as the principalantimicrobial ingredient, as well as arelatively low concentration of lauric arginate as an additive. In someembodiments, advantageous ingredient ratios ofthe citrus extracts to lauric arginate are provided. In some embodiments,formulations comprising the citrus-basedantimicrobial compositions and taste-enhancing agents are provided, which maskthe unpleasant taste that may beassociated with the citrus extract, allowing for its use in food products.Methods of preparing antimicrobial citrusextracts and antimicrobial compositions, uses thereof, and products comprisingsame are also described.