A biological nerve guide for implantation into a human body is made by a methodthat includes the steps of providing a natural animal tissue membrane, crosslinkingand fixing the membrane, minimizing the antigens from the membrane, tanningthe membrane, and coupling an active layer to the inner surface of the membrane,cutting the membrane into desired shape and size, positioning the cut of membraneonto a rod-shape mold so that the cut of membrane assumes a cylindrical configuration,and attaching a spiral support (2) to the outer surface of the cut of membrane.
