HAUSTEDT, LARS OLE,AMBROSI, HORST,DIETER - SAUPE, JOERN,GIBSON, CHRISTOPH
申请号：
ARP180103444
公开号：
AR113839A1
申请日:
2018.11.23
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
1. The compounds in this list are calculated according to the general formula (1)；1. A target country for bradiquinina (BK) B2 receptor； a pharmaceutical component containing one or more current compounds； a preparation containing at least one current compound and at least one other active pharmaceutical ingredient； and the use of such a compound,Including drug use. 1. Claim 1: it consists of general formula (1) or its salts, wherein a represents a set of formulas (2)；A1 is n or CH； A2 is n or c-ra2；A3 is n or c-ra3；a. A8308es NH, O S； a83099 is n-ra83099；Ra1 represents a hydrogen atom or a methyl group； each ra2 and RA3,Independent of each other,1. Hydrogen atom, halogen atom, oh, CN, nh832222；1. Apartment c83218331；Capable of being replaced by one or more groupsFor the same or different halogen atoms, oh, = O and nh832222 are selected；Alcoxi C8321883318323237A，Capable of being replaced by one or more groupsFor the same or different halogen atoms, oh, = O and nh832222 are selected；4.Alcoxy C83222283318325；Capable of being replaced by one or more groupsFor the same or different halogen atoms, oh, = O and nh832222 are selected；c（o）NRB 2；o NRB 1；RB1，RB Ra§83099；Everyone is independent,1. Represents a hydrogen atom or a focal length group of c833218331832323；Capable of being replaced by one or more groupsFor the same or different halogen atoms, oh, = O and nh832222 are selected；R1 represents a rental group c83321353183238o alcosiquilo c832283318c83325；This group may be replaced by one or more groups.a. Choose the same or different deuterium and halogen atoms, oh = - O and nh832222；R2 represents hydrogen atom or deuterium atom； R3 represents hydrogen atom； tar group c8331833233 or halide group c83323131；E stands for aged 3 or HCB； HCB represents a partially unsaturated or aromatic singlet or bicyclic heteromorphism, each with 3 to 10 C atoms and 1 to 4 heteroatoms.Selected from n or s, this heterocycle is not replaced, or can be replaced by one halogen atom alone or by
