The present invention is trans-1-(4-Chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)urea (trans-1-(4-Chloro-3-trifluoromethyl-phenyl) )-3-(4-hydroxy-cyclohexyl)-urea, UC2288) as an active ingredient, relates to a pharmaceutical composition for the treatment or prevention of Parkinson's disease, the UC2288 of the present invention is the development of neurons (Neuron) through inhibition of p21 activity Blocking the decrease in protein that affects the disease will be useful for the prevention and treatment of Parkinson's disease.본 발명은 트렌스-1-(4-클로로-3-트리플루오로메틸-페닐)-3-(4-하이드록시-사이크로헥실)유레아(trans-1-(4-Chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea, UC2288)를 유효성분으로 하는 파킨슨 질환 치료 또는 예방용 약학적 조성물에 관한 것으로, 본 발명의 UC2288는 p21 활성 억제를 통해 뉴런(Neuron)의 발달에 영향을 미치는 단백질 감소를 차단함으로 파킨슨 질환의 예방 및 치료에 유용하게 이용할 수 있을 것이다.
