Disclosed is a process for isolating from a reaction mixture a salt of a mono-propargylated aminoindanhaving the structure (I) wherein Ris H, hydroxyl, alkoxy or (II) whereinY is 0 or S； R and R is each independently, Calkyl, C aryl, C aralkyl, each optionally halosubstituted, or hydrogen ； where the reaction mixture further comprises a solven,a primary aminoindan having the structure (III) wherein R is definedas above, and a tertiary aminoindan having the structure (IV) the process comprisingd) adding an acid to the reaction mixture； e) crystallizing the mono-propargylated aminoindanunder conditions suitable for the formation of a crystalline salt of the mono-propargylatedaminoindan ； and f) recovering the crystalline salt of the mono- propargylatedaminoindan, wherein the process is performed without addition of an organicsolvent. Also disclosed are the crystalline diastereomeric salts producedby the process and pharmaceutical compositions containing the salts.
