A power injector syringe clamp assembly (300) is disclosed. This clamp assembly (300) includes a first clamp member (302) and a second clamp member (312), where at least one of these clamp members (302, 312) is movable to provide open and closed configurations for the clamp assembly (300). The clamp assembly (300) also includes at least one RFID reader antenna for communicating with at least one RFID tag (336) on a power injector syringe (330), at least when positioned within the clamp assembly (300).