INHIBITEUR D'URAT1 DE TYPE ACIDE CARBOXYLIQUE CONTENANT UNE STRUCTURE DIARYLMÉTHANE, MÉTHODE DE PRÉPARATION ET UTILISATION CORRESPONDANTE

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专利权人:

Ltd.;Tianjin Institute of Pharmaceutical Research Co.

发明人:

ZHAO, Guilong,LIU, Wei,SHANG, Qian,ZHOU, Zhixing,WANG, Yuli,LI, Yuquan,ZHANG, Haizhi,LI, Chuan,LIU, Changying,LIU, Yuqiang,XIE, Yafei,WU, Jingwei,CHEN, Huihui,XU, Weiren,TANG, Lida

申请号：

EP16785934

公开号：

EP3290408A4

申请日:

2016.04.28

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, wherein R 1 is selected from H, C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, F, Cl, Br, I, CN, NO 2 , SR 4 or OR 4 ； R 2 is selected from H, F, Cl, Br or I； R 3 is selected from H or C 1 -C 4 alkyl； X is selected from S or CH 2 ； wherein R 4 is selected from C 1 -C 10 alkyl.

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