Andrew J. Murphy,Lynn Macdonald,Chunguang Guo,John McWhirter,Vera Voronina
申请号：
US16442063
公开号：
US20190380316A1
申请日:
2019.06.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Non-human animals and methods and compositions for making and using them are provided, which non-human animals have a genome comprising an engineered or recombinant diversity cluster within an immunoglobulin heavy chain variable region, which engineered or recombinant diversity cluster comprises an insertion of one or more DH segments that are each operably linked to a 23-mer recombination signal sequence. Methods for producing antibodies from non-human animals are also provided, which antibodies optionally contain human variable regions and rodent, e.g., constant regions.
