The present invention relates to the new medicine applications of a Plant Extracts, more particularly to from wedelolactone preparation reducing blood lipid, prevention and treatment nonalcoholic fatty liver drug in application and drug, the drug contain the wedelolactone and one or more pharmaceutically acceptable excipient of effective dose. Before making the present invention, do not find that wedelolactone has the function of reducing blood lipid, prevention and treatment nonalcoholic fatty liver, inventor has found that wedelolactone has the function of significant reduction serum total cholesterol, triglycerides, low-density lipoprotein. Meanwhile reducing liver lipids, mitigating hepatic lipid peroxidation level, there is prevention effect to fatty liver caused by what hyperlipidemia model, wedelolactone can be developed in reducing blood lipid, prevent the application of fatty liver medicament.本發明涉及一種植物提取物的新醫藥應用，具體涉及自蟛蜞菊內酯在製備降血脂、防治非酒精性脂肪肝藥物中的應用及藥物，所述藥物含有有效劑量的蟛蜞菊內酯和一種或多種藥學上可接受的賦形劑。在本發明之前，未發現蟛蜞菊內酯具有降血脂、防治非酒精性脂肪肝的作用，本發明發明人發現蟛蜞菊內酯具有顯著的降低血清總膽固醇、甘油三酯、低密度脂蛋白的作用。同時，降低肝臟脂質、減輕肝臟脂質過氧化水平，對於高脂模型所導致的脂肪肝具有預防作用，可以開發蟛蜞菊內酯在降血脂，預防脂肪肝藥物的應用。
