PERKINTON, MICHAEL,SCHOFIELD, DARREN,IRVING, LORRAINE,THOM, GEORGE
申请号：
CA3025987
公开号：
CA3025987A1
申请日:
2017.06.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention provides antibodies that specifically bind human I-synuclein with a high affinity and reduces I-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating I-synuclein antibodies, and methods of using I-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.
