SE YOUNG LIM,SUNG HEE PARK,SE CHANG KWON,RYOUNG AE SHIN,IN YOUNG CHOI
申请号：
ARP130100760
公开号：
AR090287A1
申请日:
2013.03.08
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
This component maintains a relatively high level of peptide activity in the body and greatly improves the average blood life span, thus preventing the accumulation of triglycerides, which is a typical feature of nonalcoholic fatty disease. Finally, it can be properly used to prevent and treat nonalcoholic fatty liver disease. Claim 1: pharmaceutical ingredients for the prevention or treatment of nonalcoholic liver disease,It consists of a non insulin peptide mixture made of insulin-4 mixed peptide and an immunoglobulin region using a non cucumber polymer as the active ingredient, wherein the insulin-4 peptide selected from the insulin-4 group, Exendina-4 derivative was prepared by amino phase out group at N-terminal of exendina-4 terminal. The derivative was prepared by replacing the amino group at N-terminal of exendia-4 with a hydroxyl group,Exendina-4 derivative is produced by modifying the amino acid terminal group of exendia-4, which contains a group of dimethyl and an exendina-4 derivative. The derivative is produced by removing α - carbon from the residue of N-terminal terminal of exendia-4 and carbon a of N-terminal group, Non spicy polymers are selected from polyethylene, polypropylene glycol, ethanol propylene glycol copolymer, tetraethyl alcohol, polyethylene alcohol, polyurethane, glucose, polyethylene vinyl ether, biodegradable polymer, aliphatic polymer, kitina, hyaluronic acid and compositions. It's all the sameLa composición mantiene la actividad in-vivo del péptido en un nivel relativamente alto y aumenta notablemente la vida media en sangre, con lo cual se previene la acumulación de triglicéridos que es una característica típica de la enfermedad del hígado graso no alcohólico. Finalmente, se puede emplear convenientemente para prevenir y tratar la enfermedad del hígado graso no alcohólico. Reivindicación 1: Una composición farmacéutica para la prevención o el tratamiento de la enfermedad del hígado graso no alcohólico, caracterizada porque comprend
