IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY STATE HIGHER EDUCATIONAL INSTITUTION;KAVETSKYI INSTITUTE OF EXPERIMENTAL PATHOLOGY, ONCOLOGY AND RADIOBIOLOGY OF NAS OF UKRAINE"
A method for predicting the effectiveness of radiation therapy (RT) of patients with rectal cancer, which involves determining of organic transformations and changes in the biopsy material of a patient, and the material of the patient is converted into the homogenate, it determines the rate of superoxide generation, and the level of a marker of oxidative DNA damage is determined twice in the daily patient urine volume in nmol 8 oxoguanine (8-oxoG) - before starting the PT and one day after the patient gets the first irradiation fraction, which assist in forecasting the PT efficiency, when there are favorable prognostic factors indicating the level of radiosensitivity of the tumor, using value of velocity generation rate of superoxide radicals by tumor cells to treat more than 1.0 nmol/min•h of the fresh weight, the low level of daily excretion of 8-oxoG with urine before treatment - less than 0.5 nmol/day•kg of the body weight and growth of the level rate of 8-oxoG in the urine of the patient one day after the beginning of the PT by 50% or more in regard to the baseline, taking into account that when a favorable prognosis factor of the PT effectiveness forecast is absent, it is diagnosed as negative, and when 1-2 factors are present a moderately effective treatment is predicted and if all three factors are present a high PT efficiency is predicted.Способ прогнозирования эффективности лучевой терапии (ЛТ) у больных раком прямой кишки, которая заключается в определении органических преобразований и изменений в биопсийном материале больного, причем биопсийный материал больного превращают в гомогенат, в нем определяют скорость генерирования супероксидных радикалов, и дополнительно в суточной моче больного дважды определяют уровень маркера окислительного повреждения ДНК в нмоль 8 оксогуанина (8-oxoG) - до начала ПТ и через сутки после получения больными первой фракции облучения, по которым осуществляют прогноз эффективности ПТ, при этом есть благоприятные прогностические
