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Fenilimidazol compounds
专利权人:
INC.;OTSUKA PHARMACEUTICAL FACTORY
发明人:
AKIKO ISHIMARU,HIKARU NAKATA,HIDENORI YOSHIOKA,DAISUKE MORI,SATOSHI KIDO,TADAO SHIBUTANI,KOUSHI IWATA
申请号:
ARP160104014
公开号:
AR107191A1
申请日:
2016.12.23
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
A compound (chemotherapeutic agent) that is effective in the prevention and treatment of hyperlipidemia, obesity, or similar diseases. Claim 1: a phenyl diazo compound represented by formula (1),or a pharmaceutically acceptable salt thereof, where R¹ is (1-1) hydrogen, (1-2) pyrazolyl, (1-3) pyrimidinyl, (1-4) pyridyl having one or two substituents selected in each case in form independent from the group consisting of halogen, cyano, C₁₋₆ alkyl, C₁₋₆ alkylsulfonyl, and C₁₋₆ alkyl substituted by halogen, (1-5) oxazolyl having one or more C₁₋₆ alkyl groups, (1- 6) pyrazinyl optionally substituted with at least one group selected from the group consisting of halogen and C₁₋₆ alkyl,(1-7) phenyl having one or two substituents independently selected in each case from the group consisting of halogen and C₁₋₆ halogen substituted alkyl, (1-8) (1-pyridine oxide) yl having one or two substituents independently selected in each case from the group consisting of halogen and C₁₋₆ halogen substituted alkyl, (1-9) halogen substituted thiazolyl, (1-10) C₁₋₆ alkyl substituted isoxazolyl, (1-11) 1,2,4-oxadiazolyl substituted with C₃₋₈ cycloalkyl, or (1-12) phenyl; R² represents hydrogen or C₁₋₆ alkoxy; R³ is (3-1) hydrogen, (3-2) C₁₋₆ alkoxy,(3-3) C₁₋₆ alkoxy-C₁₋₆ alkoxy, (3-4) C₁₋₆ alkyl, (3-5) halogen, (3-6) benzyloxy, or (3-7) hydroxy; R⁴ is (4-1) pyridyl which optionally has at least one substituent selected from the group consisting of halogen, cyano, hydroxy, pyrrolidinyl, C₁₋₆ alkyl, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, C₁₋₆ alkoxy, and C₁₋₆ alkyl substituted by halogen, (4-2) C₃₋₁₀ cycloalkyl optionally having one or two substituents independently selected in each case from the group consisting of halogen and C₁₋₆ alkyl, or (4-3 ) lower alkyl; R⁵ is (5-1) hydrogen, (5-2) C₁₋₆ alkyl,or (5-3) C₁₋₆ alkoxy; R⁶ is (6-1) hydrogen, (6-2) C₁₋₆ alkoxy-C₁₋₆ alkyl, or (6-3) C₁₋₆ alkyl optionally substituted with one or more C₃₋₁₀ cycloalkyl groups, where R⁶ binds to only one of N in posit
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