Gregory T. Zugates,Andreas Zumbuehl,Robert S. Langer,Daniel Griffith Anderson
申请号：
US13312224
公开号：
US20120149630A1
申请日:
2011.12.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
