NOUVELLES FORMES CRISTALLINES D'INHIBITEURS BENZOQUINOLINE DE TRANSPORTEUR DE MONOAMINES VESICULAIRE 2

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专利权人:

APOTEX INC

发明人:

SOUZA, FABIO E. S.,KHALILI, BAHAREH,REY, ALLAN W.

申请号：

CA3043075

公开号：

CA3043075A1

申请日:

2019.05.13

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention provides novel crystalline forms of Deutetrabenazineand Tetrabenazine. Specific crystalline forms provided by the presentinventioninclude Deutetrabenazine Form APO-I, a co-crystal of Deutetrabenazine andquercetin； Deutetrabenazine Form APO-II, a co-crystal of Deutetrabenazine andluteolin； Tetrabenazine Form APO-I, a co-crystal of Tetrabenazine andquercetin；and Tetrabenazine Form APO-II, a co-crystal of Tetrabenazine and luteolin.Alsoprovided are pharmaceutical compositions comprising the Deutetrabenazine andTetrabenazine crystalline forms, and the use of these forms in the treatmentoftardive dyskinesia and chorea associated with Huntington's disease.

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中国工程科技知识中心

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http://www.ckcest.cn/home/